Why We Should Be Cautious about the 'Game-Changer' Ebola Vaccine (Al Jazeera English)

In early May 2018, when the ninth Ebola outbreak in the Democratic Republic of Congo threatened to spread to Mbandaka, a city of 1.2 million people, the global health public relations machine went into overdrive...Unlike previous outbreaks in the country, or unlike the 2014-16 West African outbreak, international responders quickly announced their support for efforts to contain Ebola...

Among the highlights of this rapid response is the use of the "investigational" rVSV-ZEBOV Ebola vaccine. Beside two vaccines developed and approved by Russia and China, this one has gone the furthest in its development: it has been tested for safety, for its ability to elicit sufficient immune response to fight off Ebola, and for efficacy...

Most media coverage about the vaccine's deployment to the region has been triumphalist, referring to the vaccine as a "game-changer" and "a paradigm shift". But these reports should be viewed with caution...As noted by Liberian academic Robtel Neajai Pailey, there is a history of medical experimentation among vulnerable populations in the US and parts of Africa. Informed consent by research participants requires a complex negotiation under any circumstances, but the history of experimentation Pailey and others describe too often intensify community concerns and negative responses to certain medical interventions...